Symptoms Elevated IL-6

IL-6 Level	Symptoms	Health Impact	Example Conditions
Normal/Low	No noticeable symptoms	Supports immune function and response to infection	Healthy immune response
Moderate Increase	Mild fatigue, occasional brain fog, low energy, mild impatience, occasional insomnia, mild irritability	Mild inflammation, early metabolic changes	Chronic stress, mild insulin resistance, early-stage metabolic syndrome
Elevated	Persistent fatigue, muscle aches, low mood, mild depression, increased impatience, early signs of resentment, occasional anger, occasional panic attacks, insomnia, mild ear ringing, intrusive thoughts	Ongoing low-grade inflammation, mental health impact	Depression, anxiety, moderate cardiovascular risk
High	Joint pain, high blood pressure, poor focus, moderate depression, heightened impatience and resentment, frequent anger outbursts, frequent panic attacks, disturbed sleep or chronic insomnia, skin reactions (e.g., hives), moderate ear ringing, frequent intrusive thoughts	Increased risk of chronic inflammation and disease	Rheumatoid arthritis, hypertension, type 2 diabetes
Very High	Severe fatigue, cognitive decline, intense pain, severe mood instability, major depression, prominent resentment, intense anger and rage, panic attacks, persistent insomnia, strong ear ringing, intensified intrusive thoughts, possible delusions	Significant inflammation affecting multiple systems	Cardiovascular disease, severe autoimmune disorders, cancer progression
Extremely High	Organ damage, immune dysfunction, extreme anxiety, disorientation, persistent delusions, psychosis, severe ear ringing, hallucinations, unrelenting insomnia, obsessive intrusive thoughts, severe depression, uncontrollable rage, potential catatonia	Life-threatening inflammation, systemic complications	Sepsis, severe COVID-19, cytokine storm
Critical	Complete organ failure, severe psychosis, catatonia, uncontrolled delusions, auditory and visual hallucinations, unrelenting ringing in the ears, near-total loss of cognitive function, death	Systemic collapse due to uncontrolled inflammation	Terminal sepsis, advanced inflammatory disease, cytokine storm-related death